Moving forward, the results of the phase 3 SURPASS clinical trial program demonstrated that tirzepatide was as effective and safe as other anti-diabetic agents, such as semaglutide and dulaglutide (SURPASS-2) (SURPASS J-mono), long-acting insulin analogs (degludec and glargine) (SURPASS-3,4), and placebo (SURPASS-1) (SURPASS-5), in managing T2DM diabetes [65,66,67,68,69]
For this purpose, they reviewed the role of high-dose GLP-1RAs, such as Liraglutide 3 mg, Semaglutide 2 and 2.4 mg, Dulaglutide 3 and 4.5 mg, TZP, and the dual agonist glucagon/GLP-1 Cotadutide (72)
High five
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