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Molecular docking studies revealed that 36 formed a hydrogen bond with the Glu1261 residue, however, a crucial interaction through hydrogen bonding with the Arg768 residue present in topiroxostat, was absent in 36 , and this may be one of the reasons for the decrease in inhibitory activity in relation to the drug [64]
Both medications influence serotonin pathways, though through different mechanismssemaglutide affects appetite-control neurons while Lexapro modulates mood-regulating circuits throughout the brain
For detection of the ROS, root samples were completely suspended in 0.1% (w/v) 2',7'-Dichlorodihydrofluorescein diacetate (H 2 DCFDA, Sigma Aldrich) solution under dark for 15 min
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