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A 12-week study in humans where participants were given 500mg of berberine 3 times a day resulted in: an average weight loss of 5lb (2.3kg) a 23% reduction in triglycerides (a type of blood fat) a 12.2% reduction in cholesterol However, animal studies show that berberine has a very low bioavailability of less than 1% (how much of it is absorbed in your bloodstream), which may affect its effectiveness

Many posts described using smaller doses, including semaglutide microdosing, as a way to manage side effects, extend medication supply, or navigate access barriers

10.1177/20420188221112490 86 WeiY.MojsovS

Pathologically elevated ICP can be reduced by nearly 50% in rats with intracranial hypertension treated with exenatide, with effects sustained over a week