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Osteocalcin induces proliferation via positive activation of the PI3K/Akt, P38 MAPK pathways and promotes differentiation through activation of the GPRC6A-ERK1/2 pathway in C2C12 myoblast cells

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3.2 Systematic reviews and meta-analyses: three tiers of critical evidence Existing secondary research can be broadly categorized into three tiers: (i) PCOS-specific meta-analyses of RCTs (primarily focusing on weight, metabolism, and select endocrine markers)