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In addition, the delivered cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) siRNA (NPsiCTLA-4) can deliver CTLA-4 siRNA to CD4 (+) and CD8 (+) T cell subsets at the tumor site, significantly increasing CD8 (+) T cells and reducing the proportion of Tregs, while also enhancing the activation of tumor-infiltrating T cells and antitumor immune responses (173)

Cardiovascular Function Both IGF-1 and GH are partially responsible for cardiovascular system development and protection

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In addition, it is reported that specific cytokines can alter GSH levels in antigen presenting cells [81]