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In animal and cellular models, its involvement in the modulation of pancreatic beta cell function and in the regulation of signaling pathways related to glucose metabolism has been demonstrated

[6] [18] The standard titration schedule begins at 0.25 mg once weekly for four weeks (an initiation dose not intended for glycemic control), followed by escalation to 0.5 mg weekly

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In this study 35 (56%) patients exposed to GLP-1RAs had an increased incidence of RGC as compared to 12 (19%) of the non-users, a finding that persisted after adjustment for confounders