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Research on the association of DPN and the nutrient-related complication of T2DM has received a lot of research interest due to its impact on the quality of life and rehabilitation strategies of the patients

Her predicted creatinine clearance is 22 mL/min (Cockcroft & Gault), so for digoxin, her renal clearance is 6 22/100 60/70 = 1.1 L/h, nonrenal clearance 2.7 60/70 = 2.6 L/h, and total clearance 3.7 L/h

Dosing Dosing recommendations were explored in a multicenter double-blind RCT conducted with 181 patients with DPN, comparing doses of 600-1800 mg/d oral ALA to placebo