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Unexpectedly, SNPs related to HIF/EPO pathway genes ( EGLN1 , EGLN2 , EGLN3 , EPO , EPOR , HIF1A , PTEN , and VHL ) have failed to establish a definitive correlation with CMS susceptibility among male Peruvian Quechua natives, potentially due to flawed grouping: non-CMS controls lacked strict criteria (non-CMS: individuals with a CMS score 3000 m, prophylaxis should be strongly considered
Additional etiologies that may mimic Reyes syndrome include viral infections, neuromuscular diseases, adverse drug reactions, and exposure to toxic chemicals and plants that cause hepatocellular damage and encephalopathy
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