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(February 2016)

Through bioinformatics analysis, some researchers found that hexamethylmelamine (altretamine), an antitumor drug approved by the US FDA for the treatment of ovarian cancer, can inhibit the lipid repair activity of GPX4, suggesting the potential mechanism of its antitumor activity [129]

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In our study, the test variation of OCCT does not change the fact that the low-TMAO producers were influenced more than high-TMAO producers by the carnitine supplement because the trends were consistent with several analytical results including using both data of OCCT TMAO MAX and TMAO AUC from plasma and urine