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Zileuton, a 5-LOX inhibitor approved by the FDA and formerly employed in the treatment of asthma, is presently under evaluation for clinical trials in the management of PF [189]

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The active CASSCF zones included all orbitals (and electrons) that, due to their coupling, transfer significant electron densities from one orbital to another, because of this being located in the so-called HOMO-LUMO zone

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