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Increased c-MET and TGF- pathway activity may promote tumor progression in glioblastoma via invasion, migration, angiogenesis, cell survival, SC maintenance, and immune evasion 13,23,24,25,26,27,28 , however, their potential interactions may not have been sufficiently studied

Funding This work was supported by the National Key Research and Development Program of China (2019YFE0108200), Sichuan International Science and Technology Cooperation Project (2022YFH0023), Science Popularization Base Project of Chengdu Science and Technology Bureau (2022-GH03-00003-HZ), West China Hospital 1.3.5 Project for Disciplines of Excellence (21HXFH002), West China Hospital Hospital-Enterprise Cooperation Clinical Research Innovation Project (2021HXCX04), and the National Natural Science Foundation of China (82001728)

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The values obtained in the presence of KA and HQ were calculated from LineweaverBurk plots (Figs 1 and 2