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In addition, various cytokines and hormones contribute to elevated portal pressures by inducing splanchnic vasodilation and an increase in splanchnic flow

doi: 10.1016/j.pneurobio.2010.07.003 25 LarsenPVrangNTang-ChristensenM

In addition, during vaso-occlusive episodes, SCD patients show distinct metabolite profiles from those at steady-state 7,8,9,10

Antidepressants and gut microbiota Nowadays, neither monotherapy nor the use of antidepressants in rapid cycling BD is recommended, but antidepressants can be used as adjunctive treatment in BD as a second-line treatment