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Enhancing stem cell function via culturing under hypoxic condition, which is known to prime MSCs to reduce cellular ROS levels, improved chondrogenic differentiation of MSCs [20] and cartilage regeneration in both post-traumatic and focal early OA rabbit models [21]

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Their action signals the cell to modulate its response, through the recruitment of endogenous coping mechanisms, among which are an increased synthesis of antioxidants and of electrophile quenchers, the transcription of the necessary gene products and the production of reducing cofactors such as NADH/NADPH and ascorbate

Resmetirom, as an oral medication, is a promising solution as it is safe and well-tolerated for long-term use and provides more convenience and accessibility for patients who may be afraid of injections