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This is likely because GLP-1 agonists can delay the emptying of bile from the gallbladder

However, the best results are seen when these medications are used in addition to committed diet and exercise, as they make the lifestyle changes much easier to adhere to

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Why GLP-1 Medications Can Make Symptoms Worse GLP-1 medications can amplify these issues in a few ways: Changes in appetite and eating patterns Increased sensitivity to fullness and pressure Altered breathing patterns due to discomfort Increased abdominal guarding or bracing When breathing mechanics shift and the diaphragm is not moving well, pressure is often redirected outward into the abdomen instead of being managed efficiently within the system