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It has been suggested in the early Covid-19 pandemic that overexpression may increase the risk of SARS-CoV-2 infection (Peron and Nakaya 2020)

Semaglutide and tirzepatide are FDA-approved with extensive clinical trial data showing average 15-20% body weight loss, improvements in cardiovascular health markers, reduction in obesity-related disease risk, and excellent safety profile with proper medical supervision

Effects of GLP-1 agonists on proportion of weight loss in obesity with or without diabetes: Systematic review and meta-analysis

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