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Description

Exendin-4 significantly increased insulin level and phosphorylation of insulin receptor substrate 1 (IRS-1) in rat hippocampus, and could not change the status of tau phosphorylation without insulin in HT22 neurons, suggesting that insulin is required in reduction of tau hyperphosphorylation by GLP-1R agonists (154)

Mediators of Inflammation

Chronic low-grade inflammation contributes to obesity-related comorbidities [123, 124], and the MD has consistently demonstrated immunomodulatory effects, even in the absence of weight loss [123, 124]

10.1161/CIRCULATIONAHA.117.029166 131