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Recent studies further highlight the role of metabolic reprogramming in tubular repair, with defective fatty acid oxidation in aged kidneys exacerbating post-IRI maladaptive repair (Mylonas et al., 2021)

Of note, oxidized MSH is unable to rescue suppression of Nrf2 and Nrf2dependent gene expression

Blood 103:517522 Delbridge AR, Aubrey BJ, Hyland C et al (2017) The BH3-only proteins BIM and PUMA are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL

Minerals, on the other hand, are not antioxidants themselves