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A42 oligomer induces the upregulation of RAGE on BECs and BBB leakage in vitro (Wan et al., 2015)

Ipamorelin's GHSR-1a mechanism is additive to GHRH-pathway stimulation because the two receptor systems converge on different intracellular signaling pathways (Gs-cAMP for GHRHR, Gq-PKC and MAPK for GHSR-1a) and can both stimulate somatotroph GH release simultaneously

clinical and experimental aspects

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