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Notably, the mechanism for the aggregate formation of the GST fusion protein remains poorly understood

In patients with castration-resistant prostate cancer (CRPC), elevated baseline IL-6 was correlated with poor survival, and siltuximab treatment resulted in a 23% stable disease (SD) rate [348]

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The susceptibility of erythrocytes to eryptosis in glucose-6-phosphate dehydrogenase deficiency was attributed to oxidative stress [234], while in sickle cell disease Ca 2+ entry was reported to be facilitated by ceramide [233]