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Most rodent studies used: 10 micrograms/kg 100 micrograms/kg Administration routes varied by study: Intraperitoneal injection Subcutaneous injection Oral administration in drinking water Example reference: Sikiric et al., 2018 These dosages reflect controlled laboratory conditions and are not generalised outside experimental models

Some researchers tolerate dose increases faster

As you see an increase in Vitamin B12 levels, only doctors can decide to change the levels of the dosage relying on the changing body conditions

These research models are designed to evaluate biochemical pathway activity and cellular signaling responses , not therapeutic outcomes