Porter DW, Irwin N, Flatt PR, Hlscher C, Gault VA: Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice
The possible mechanisms may involve effects on GLP-1 hormones, the authors of the trial hypothesize, "that are secreted from the gastrointestinal tract and affect appetite by regulating digestive processes and neural signaling in the central nervous system." Medicinal plants are also turning out to be fruitful areas of research
GLP-1 suppresses gastrointestinal motility and inhibits the migrating motor complex in healthy subjects and patients with irritable bowel syndrome
In contrast, the low dose of GLP1/GIP failed to persistently improve body weight, body composition, or food intake, but significantly ameliorated glucose handling and insulin sensitivity, and reduced basal glucose levels vs