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Biochemical and omics biomarkers in cognition Classical CSF and plasma biomarkers A40 / A42 (important ratio in amyloid pathology) Total tau / p-tau181 / p-tau217 (tauopathic markers) Neurofilament light (NfL) : axonal degeneration marker GFAP : astrocytic activation BDNF and pro-BDNF : neurotrophic activity IL-6, TNF, IL-1 : neuroinflammation Transcriptomics and epigenomics Hippocampal RNA-seq after chronic administration of Semax or Selank often reveals a neurotrophic activation signature (BDNF, NT3, NGF, NR4A1-3) coupled with anti-inflammatory modulation (NF-B targets down)

You take metformin or a proton pump inhibitor, which can deplete B12 over time

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This is why many clients notice a difference in energy and clarity within 48 to 72 hours of their first injection