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this, in turn, resulted in the upregulated expression of telomere repeat-binding factor 1/2 (TRF1/TRF2) proteins and strict dependence on p53/p21 signaling, followed by irreversible G2/M cell cycle arrest, ultimately leading to apoptosis

10.1242/jcs.065284 J

1 Like Davin8r February 20, 2023, 6:02pm #8 I guess well see if theres some other physiological mechanism that specifically causes lean mass loss with these drugs, but my understanding was that the final weight loss mechanism is simply decreased appetite and hence decreased caloric intake

Engs persistence, nurtured by his training under a Nobel laureate who had herself challenged orthodoxy, kept the idea alive long enough for science to catch up