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High doses of PQQ shown preventive effects against hypoxic/ischemic damages, seizures induced by chemical agents, inflammation from carrageenan, ethanol or carbon tetrachloride (CCl 4 )-induced liver damage, cataract formation, glutathione depletion in glucocorticoid-treated chicken embryos, and endotoxin-induced death in in vivo models (He et al., 2003

*OL: Off-label medications

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The high preference for NADP+ over NAD+ by glucose 6-phosphate dehydrogenase allows reductive biosyntheses and glycolysis to occur simultaneouly at a high rate.