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Caffeine's phosphodiesterase (PDE) inhibition sustains elevated cyclic AMP (cAMP) levels in adipocyte tissue, prolonging the activation of hormone-sensitive lipase (HSL) and extending the fat release window beyond what hormonal lipolytic signals alone would maintain

These drugs are called GLP-1 receptor agonists because they can bind to GLP-1 receptors and produce the same effects as the naturally occurring GLP-1 hormone

Biol Psychiatr 2017;81:40210

J Clin Invest Chavoshinezhad S et al (2021) Optogenetic stimulation of entorhinal cortex reveals the implication of insulin signaling in adult rats hippocampal neurogenesis