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Most adults tolerate doses up to 500 mg per day without serious side effects

a Journal Technical Methods Pathology 100 (6), 801811

10.1038/s41467-022-35256-8 355 ZhangX.LuoS.WangM.HuangQ.FangW.LiJ.et al (2022b)

Bipolar disorder In addition to schizophrenia, study demonstrated an association between homozygous 677TT genotype of MTHFR gene and bipolar disorder with stronger linkage in male patients than female patients 46