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In overdose, the concentrations of 3-phosphoadenosine 5-phosphosulphate (PAPS) (for sulphation) and glutathione (for cytoprotection) are depleted, and extensive macromolecular binding leads to hepatocellular necrosis

Quality of life improvements following one year of setmelanotide in children and adult patients with BardetBiedl syndrome: phase 3 trial results

One of the papers that laid the foundation stones of the pathway was Foyer and Halliwell (Planta 133:2125, 1976)

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