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Randomized controlled trials have demonstrated 60 to 100% reductions in NTD cases when women consumed folic acid supplements in addition to a varied diet during the month before and the month after conception

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While the research shows promise, especially for heart failure and after heart attacks, there are concerns about a byproduct called TMAO, which might increase the risk of clogged arteries

The main reason for using NEM, IAA or 2-VP is not the improvement of the LC and MS/MS properties of GSH, but to avoid artificial oxidation of GSH to GSSG, even if, as stated before, they are not equally effective to this purpose