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To view or add a comment, sign in More Relevant Posts Prolonged ASM exposure increased malformation risk, and valproate- or some lamotrigine-based dual therapies showed higher malformation risks associated with these combinations

Indeed, the PDH complex, which decarboxylates glycolytically derived pyruvate to acetyl coenzyme A and links cytoplasmic glycolysis to the mitochondrial tricarboxylic acid (TCA) cycle, is modulated by reversible phosphorylation by PDH kinase (PDK)

"I really want to see that this is going to work well and deliver results for patients, but I also want to see that it's something that my patients can stay on long term," Dr

Andreeff M , Wong G, Koziner B, Espiritu E, Clarkson B