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Optimal absorption, retention and utilisation

Ghrelin acts on reward-related pathways by stimulating dopamine neurons in the ventral tegmental area and promoting dopamine turnover in the nucleus accumbens, a region of the ventral striatum ( Preclinical models indicate that the GLP-1 R system has evolved, at least in part, to regulate feeding-related motivation ( Repeated dosing is probably crucial for positive effects in depression and suicidality

The PK profile after a single subcutaneous (s.c.) injection of 3 mg kg 1 AMG 133 in female cynomolgus monkeys is shown in Fig

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