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Various studies have reported a variable prevalence of disease, with an estimated incidence of 1.3/100,000, which increased over a period of time, and a prevalence of 13.3/100,000 (Johnson et al., 2021).In a study conducted on 921 patients with pure small-fiber neuropathy, 53% had idiopathic small-fiber neuropathy

Administration Route by Peptide Type When Injectable GHK-CU Makes Sense The injectable form provides systemic benefits that topical cannot achieve: Whole-body tissue regeneration effects Internal organ support Consistent blood levels Better bioavailability Combined with other injectable peptides When Topical Makes Sense Topical application excels for: Targeted skin treatment Hair and scalp applications Those avoiding injections Combination with skincare routines Localized wound healing For maximum benefit, some protocols use both injectable GHK-CU for systemic effects and topical copper peptides for targeted skin benefits

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