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doi: 10.1007/s13105-013-0242-y

Another study demonstrated that empagliflozin appears to primarily reduce oxidative stress in cardiomyocytes by inhibiting NHE1, consequently enhancing cardiomyocyte stiffness, promoting extracellular matrix remodelling, mitigating centripetal hypertrophy of the heart, and alleviating systemic inflammation [119]

After the initial visit, an 11-week drug dose titration period was initiated: 0.25 mg weekly for 4 weeks, then 0.5 mg weekly for 4 weeks, then 1 mg onward

a finding that supports the notion that moderate dosing may be optimal in neurodegenerative disease contexts