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[4] described the efficacy and safety of PRP in the first report on alopecia areata in a randomized, double-blind, placebo- and active-controlled, half-head, parallel-group study

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Four main MAPK cascades have been identified: ERK1/2 (extracellular signal-regulated kinases), c-Jun N-terminal kinases (JNK), p38 (p38 kinase), and the BMK1/ERK5 (big MAP kinase 1) (Schaeffer and Weber 1999)

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