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Genistein administration induced Nrf2 enhancement by activation/phosphorylation of keap1, sirt1, MAPK-ERK1/2, PKC, and estrogen receptor in other cells or tissues, such as: hippocampal tissue, hypothalamic paraventricular nucleus, ovary, and Caco-2 cells [131, 135,136,137]

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The case, which was presented at the 2024 annual meeting of the American Geriatrics Society, highlights the need to avoid GLP-1 agonists in older patients with dementia, especially those who cannot be monitored closely, says Dr