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Open Heart 1 , e000173, (2014)

27 Clinicaltrials.gov

In the case of I/R injury, systemic inflammation and the release of cytokines and LPS can enhance BBB permeability by breaking tight junctions between endothelial cells and by activating matrix metalloproteinases that breakdown the extracellular matrix (S-Pereira et al., 2012)

This is especially relevant to individuals with poorly functioning GST enzymes