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Glutathione-doxorubicin conjugate expresses potent cytotoxicity by suppression of glutathione S-transferase activity: comparison between doxorubicin-sensitive and -resistant rat hepatoma cells

Seek immediate medical attention for: Severe, persistent abdominal pain, especially if different from typical IBS pain or radiating to the back (possible pancreatitis) Persistent vomiting preventing adequate fluid intake Signs of dehydration (decreased urination, dizziness, extreme thirst) Severe constipation lasting more than 3-4 days without bowel movement Blood in stool or black, tarry stools Yellowing of skin/eyes, right upper quadrant pain (possible gallbladder disease) Markedly reduced urination (possible acute kidney injury) Fever accompanying gastrointestinal symptoms Neck mass, difficulty swallowing, persistent hoarseness (thyroid concerns) Allergic reactions (rash, itching, swelling, severe dizziness) Scheduled follow-up should occur within 4-6 weeks of initiating therapy and after each dose escalation

Islam R, et al

There are ongoing studies including a large phase 3 trial underway to determine if semaglutide will meet any of these clinical endpoints for FDA approval