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Cotellese et al., 2021

The practice dates back to the early 1990s, when it was used to safely study how a newly developed drug is absorbed, used and eliminated by the body

The "food noise" that constant mental loop of cravings and hunger signals gets quieter

When a cardiologist's primary clinical mandate is preventing heart attacks and strokes, and a drug demonstrates 20% reduction in major cardiovascular events, that drug becomes a cardiovascular medicine rather than a metabolic medicine