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(63) demonstrated that the DIO2 Thr92Ala polymorphism substantially reduces type 2 deiodinase activity, impairs local T4-to-T3 conversion, and is associated with lower serum T3 levels in patients treated with levothyroxine

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In imiquimod-induced lupus mice, the prebiotic Hirsutella sinensis polysaccharides and the probiotic Parabacteroides goldsteinii significantly reduced disease markers, including spleen weight, proteinuria, anti-dsDNA autoantibodies, and STAT signaling levels, while improving renal and hepatic function parameters

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