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When considering potential detrimental effects of antibodies, the presence or absence of cross-reactive antibodies against other human coronavirus (HCoV) strains has not been linked to whether SARS-CoV-2 infection is more severe, mild or asymptomatic, although antibodies that recognized the SARS-CoV-2 S2 subunit were detected in 12 out of 95 uninfected individuals 61

Ajoolabady A, Wang S, Kroemer G, Penninger JM, Uversky VN, Pratico D, et al

However, all of the ICERs reported from the modeling scenarios were in the range generally considered cost-effective in the US setting