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the dysfunctioning of the mitochondria fails to control the ROS species via some major targets/genes such as SIRT3, FOXO, and PPARGC1A, thus, enhancing the activity of the mitochondria and these genes could/maybe the option to counter the ROS level and oxidative stress to prevent the neuronal death 31

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Efficacy and safety of adjunctive bitopertin (10 and 20 mg) versus placebo in subjects with persistent predominant negative symptoms of schizophrenia treated with antipsychoticsResults from the Phase III FlashLyte Study

The rapid change in the degree of reduction of sensors with significantly less negative E values than E values of roGFP2 and roGFP1 (Table 1) can be further illustrated by the first derivative dReD/dt of the degree of reduction