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At 2.4 mg, weight typically stabilizes at a new set-point rather than declining indefinitely that is the expected, documented behavior, not a stall to fix by exceeding the labeled maximum

J Clin Neurosci 76:14

the gastrointestinal side effects and visible weight loss typical of this class threaten the integrity of trials with subjective outcomes, which again argues for objective endpoints

The field requires urgent Phase I/II human trials before any clinical recommendations can be made