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It is not recommended during pregnancy, even though it is often sought for melasma

Beyond metabolic benefits, recent studies also indicate that IF may moderate immune dysregulation by influencing critical inflammatory signaling pathways, which could have therapeutic implications for autoimmune diseases [59]

204,205 Although many HD patients may have plasma ascorbic acid levels less than the normal range, 206,207 whether this reflects a clinically significant deficiency is uncertain

The STEP trials with semaglutide demonstrated that participants regained approximately two-thirds of their lost weight within a year of stopping treatment