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Neuro Oncol (2022) 11:noac033

Reported Mild Effects: Temporary injection site redness Slight drowsiness (when dosed in evening) Vivid dreams or altered sleep patterns Mild headaches during initial days Management Strategies: Rotate injection sites regularly Reduce dosage if effects seem excessive Maintain hydration throughout protocol Consider timing adjustments for sleep-related effects When to Modify or Discontinue Certain situations warrant protocol modifications or discontinuation

Ebata H, Shima T, Iizuka R, Uemura S (2023) Accumulation of TERT in mitochondria exerts two opposing effects on apoptosis

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