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39 There are ongoing studies evaluating the efficacy of orforglipron on weight loss and cardiovascular outcomes (clinical trial number NCT05803421

A separate survey from benefits consultancy Mercer found that 5% of large employersdefined as those with more than 500 employeesalso plan to end coverage of the drugs in 2027

PlexusDx compounded formulations (semaglutide $189/mo, tirzepatide $289/mo, or GLP-Squared dual compound $289/mo) offer flexible access, allowing you to start with informed confidence and adjust based on real-world response rather than cost assumptions alone

This is the first large-scale, real-world body-composition comparison of the two market-leading GLP-1 drugs outside the trial environment and it tilts the muscle-preservation question more sharply toward semaglutide than the SURMOUNT and STEP DXA substudies suggested