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Whilst GLP-1 receptor activation can exert multiple direct neuroprotective effects, the protective influence of GLP-1 receptor agonists may occur indirectly through the restoration of the dysfunctional insulin signaling associated with neurodegenerative disease

Furthermore, an interpretable XGBoost model achieved strong performance in predicting ICU mortality among AP patients, with an external validation AUROC of 0.89, surpassing established metrics such as the APACHE IV score and the Sequential Organ Failure Assessment score

At that point, the most studied and effective tools are surgical