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The peptide is engineered with a fatty-acid moiety to extend its circulation time (half-life ~6 days), allowing for once-weekly dosing [2]

GLP-1 RAs are not suitable for everyone

Tirzepatide, used in Zepbound and Mounjaro, targets both the GLP-1 and the GIP receptor agonist, while semaglutide, found in Wegovy and Ozempic, mimics only the GLP-1 receptor agonist, a type of hormone in the body that impacts everything from the brain to muscle to the pancreas, stomach and liver

In this context, our data must be viewed as exploratory and hypotheses-generating in nature, and presented for the purpose of providing suggestions for future, more targeted investigations of the myocardial biology of GLP-1 agonism