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Frontiers in Endocrinology, 16 , 1520362

The mesolimbic dopamine system, often called the brains reward pathway, plays a central role in addiction development and maintenance across virtually all substances of abuse

A simple build-up of ATP in the medium is an unlikely explanation for our observations as the recordings were performed with relatively fast continuous perfusion (~1 ml min 1 , equalling ~3 volume replacements per minute)