These findings were further supported by Nicolau et al 5 , who demonstrated similar clinical improvements in a broader cohort with extended follow-up, thereby reinforcing the potential use of GLP-1 RAs even in patients without metabolic comorbidities
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The approval is backed by data from the pivotal Phase III PERSEUS study, where treatment with subcutaneous Darzalex Faspro reduced the risk of disease progression or death by 60% in the intended patient population compared to standard of care
For semaglutide (Ozempic and Wegovy), the manufacturing costs represented under 1% of current price
