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The increased level of insulin increases IGF-1 production by stimulating GH signaling ( 2 ( IGF-1 has been associated with the development and progression of some cancer types due to its function in activating the MAPK and PI3K signaling pathways ( in vivo study, the presence of high IGF-1 levels in the primary tumor environment tended to induce cancer cells to metastasize to bone, and cancer cell lines that highly expressed IGF1R were prone to display enlarged bone mass (50, 51)

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Signal bias, allosterism, and polymorphic variation at the GLP-1R: Implications for drug discovery