compound semaglutide hers GLP-1 Launch — Michael Jones Questions about Hers & compound

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According to a 2025 study published in JAMA Network , more than half of patients who are overweight or have obesity discontinued GLP-1 therapy within one year, and almost three-fourths of patients discontinued therapy by two years

Tirzepatide, compared to both GLP-1 and NNC0090-2746, shows biased signaling at GLP-1R, favoring cAMP response over -arrestin recruitment, which leads to low efficacy for GLP-1R internalization (108110)

Li M, Cheng W, Zhang L (2021) Maternal selenium deficiency suppresses proliferation, induces autophagy dysfunction and apoptosis in the placenta of mice